FOXN1 antibody (AA 1-160) (Biotin)

Catalog No. ABIN7153071

The Rabbit Polyclonal anti-FOXN1 antibody has been validated for ELISA. It is suitable to detect FOXN1 in samples from Human.

Quick Overview for FOXN1 antibody (AA 1-160) (Biotin) (ABIN7153071)

Target: FOXN1 (Forkhead Box N1 (FOXN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXN1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-FOXN1 Antibody (Biotin)

Binding Specificity: AA 1-160

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Forkhead box protein N1 protein (1-160AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FOXN1

Target: FOXN1 (Forkhead Box N1 (FOXN1))

Alternative Name: FOXN1

Background:

Background: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891).

Aliases: FKHL20 antibody, Forkhead box N1 antibody, Forkhead box protein N1 antibody, FOXN 1 antibody, FOXN1 antibody, FOXN1_HUMAN antibody, RONU antibody, Rowett nude antibody, Transcription factor winged-helix nude antibody, WHN antibody, Winged helix nude antibody, Winged-helix transcription factor nude antibody

UniProt: O15353