GABBR2 antibody (AA 60-310)
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- Target See all GABBR2 Antibodies
- GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))
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Binding Specificity
- AA 60-310
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GABBR2 antibody is un-conjugated
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human Gamma-aminobutyric acid type B receptor subunit 2 protein (60-310AA)
- Isotype
- IgG
- Top Product
- Discover our top product GABBR2 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))
- Alternative Name
- GABBR2 (GABBR2 Products)
- Synonyms
- Gpr51 antibody, GABABR2 antibody, GPR51 antibody, GPRC3B antibody, HG20 antibody, HRIHFB2099 antibody, Gb2 antibody, Gm425 antibody, GABA(B)R2 antibody, si:dkey-190l1.2 antibody, gamma-aminobutyric acid type B receptor subunit 2 antibody, gamma-aminobutyric acid (GABA) B receptor, 2 antibody, gamma-aminobutyric acid (GABA) B receptor, 2 S homeolog antibody, GABBR2 antibody, LOC100448699 antibody, gabbr2 antibody, Gabbr2 antibody, gabbr2.S antibody
- Background
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Background: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Aliases: BcDNA:GH07312 antibody, CG6706 antibody, CT20836 antibody, D Gaba2 antibody, FLJ36928 antibody, G protein coupled receptor 51 antibody, G-protein coupled receptor 51 antibody, GAB B R2 antibody, GABA B R2 antibody, GABA B receptor 2 antibody, GABA-B receptor 2 antibody, GABA-B-R2 antibody, GABA-BR2 antibody, GABAB R2 antibody, GABABR 2 antibody, GABABR2 antibody, GABB R2 antibody, GABBR 2 antibody, Gabbr2 antibody, GABR2_HUMAN antibody, Gamma aminobutyric acid B receptor 2 antibody, Gamma aminobutyric acid GABA B receptor 2 antibody, Gamma aminobutyric acid type B receptor subunit 2 antibody, Gamma-aminobutyric acid type B receptor subunit 2 antibody, Gb 2 antibody, Gb2 antibody, GH07312 antibody, GPR 51 antibody, GPR51 antibody, GPRC 3B antibody, GPRC3B antibody, HG 20 antibody, HG20 antibody, HRIHFB2099 antibody, Metabotropic GABA B receptor subtype 2 antibody, OTTHUMP00000021776 antibody, OTTHUMP00000063797 antibody, R2 SUBUNIT antibody
- UniProt
- O75899
- Pathways
- cAMP Metabolic Process
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