HEY1 antibody (AA 200-300)

Catalog No. ABIN7154814

Product Details anti-HEY1 Antibody

Target: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Binding Specificity: AA 200-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HEY1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Hairy/enhancer-of-split related with YRPW motif protein 1 protein (200-300AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HEY1

Target: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Alternative Name: HEY1 (HEY1 Products)

Synonyms: BHLHb31 antibody, CHF2 antibody, HERP2 antibody, HESR1 antibody, HRT-1 antibody, OAF1 antibody, AI316788 antibody, AI414254 antibody, HRT1 antibody, Herp2 antibody, Hesr1 antibody, bHLHb31 antibody, hesr-1 antibody, id:ibd1292 antibody, zgc:110572 antibody, bc8 antibody, chf2 antibody, herp2 antibody, hesr1 antibody, hrt1 antibody, oaf1 antibody, xbc8 antibody, hes related family bHLH transcription factor with YRPW motif 1 antibody, hairy/enhancer-of-split related with YRPW motif 1 antibody, hes-related family bHLH transcription factor with YRPW motif 1 antibody, hes related family bHLH transcription factor with YRPW motif 1 S homeolog antibody, HEY1 antibody, Hey1 antibody, hey1 antibody, hey1.S antibody

Background:

Background: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).

Aliases: Basic helix loop helix protein OAF1 antibody, bHLHb31 antibody, Cardiovascular helix loop-helix factor 2 antibody, Cardiovascular helix-loop-helix factor 2 antibody, CHF-2 antibody, CHF2 antibody, Class B basic helix-loop-helix protein 31 antibody, Hairy and enhancer of split related protein 1 antibody, Hairy and enhancer of split-related protein 1 antibody, Hairy enhancer-of-split related with YRPW motif protein 1 antibody, Hairy related transcription factor 1 antibody, Hairy-related transcription factor 1 antibody, Hairy/enhancer of split related with YRPW motif 1 antibody, Hairy/enhancer-of-split related with YRPW motif protein 1 antibody, HERP2 antibody, HES related repressor protein 1 antibody, HES-related repressor protein 1 antibody, HES-related repressor protein 2 antibody, HESR-1 antibody, HESR1 antibody, HEY 1 antibody, hey1 antibody, HEY1_HUMAN antibody, hHRT1 antibody, HRT-1 antibody, HRT1 antibody, OAF1 antibody

UniProt: Q9Y5J3

Pathways: Tube Formation