HNRNPD/AUF1 antibody (AA 1-306)

Catalog No. ABIN7155102

The Rabbit Polyclonal anti-HNRNPD/AUF1 antibody has been validated for WB, IHC and ELISA. It is suitable to detect HNRNPD/AUF1 in samples from Human.

Quick Overview for HNRNPD/AUF1 antibody (AA 1-306) (ABIN7155102)

Target: HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNRNPD/AUF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-HNRNPD/AUF1 Antibody

Binding Specificity: AA 1-306

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Heterogeneous nuclear ribonucleoprotein D0 protein (1-306AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HNRNPD/AUF1

Target: HNRNPD/AUF1 (HNRNPD) (Heterogeneous Nuclear Ribonucleoprotein D (HNRNPD))

Alternative Name: HNRNPD

Background:

Background: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3\\\'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5\\\'-UUAG-3\\\' sequence and also weaker to the single-stranded 5\\\'-TTAGGG-3\\\' telomeric DNA repeat. Binds RNA oligonucleotides with 5\\\'-UUAGGG-3\\\' repeats more tightly than the telomeric single-stranded DNA 5\\\'-TTAGGG-3\\\' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3\\\'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Aliases: ARE binding protein AUFI type A antibody, AU-rich element RNA-binding protein 1 antibody, AUF antibody, AUF1 antibody, AUF1A antibody, Heterogeneous nuclear ribonucleoprotein D0 antibody, hnRNP D antibody, hnRNP D0 antibody, Hnrnpd antibody, hnRNPD0 antibody, HNRPD antibody, HNRPD_HUMAN antibody, P37 antibody

UniProt: Q14103