PTPN7 antibody (pSer246)

Catalog No. ABIN711326

The Rabbit Polyclonal anti-PTPN7 antibody is suitable to detect PTPN7 in samples from Mouse. It has been validated for WB, IF (cc), IF (p), ELISA, IHC (p) and IHC (fro).

Quick Overview for PTPN7 antibody (pSer246) (ABIN711326)

Target: PTPN7 (Protein tyrosine Phosphatase, Non-Receptor Type 7 (PTPN7))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN7 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-PTPN7 Antibody

Binding Specificity: pSer246

Cross-Reactivity: Mouse

Predicted Reactivity: Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from mouse PTPN7 around the phosphorylation site of Ser246

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PTPN7

Target: PTPN7 (Protein tyrosine Phosphatase, Non-Receptor Type 7 (PTPN7))

Alternative Name: PTPN7

Background:

Synonyms: PTPN7phospho S246, BPTP 4, BPTP4, Dual specicity phosphatase 1, Hematopoietic protein tyrosine phosphatase, LC PTP, LCPTP, LPTP, Protein tyrosine phoshatase non receptor type stress induced, Protein tyrosine phoshatase nonreceptor type stress induced, Protein tyrosine phosphatase LC PTP, Protein tyrosine phosphatase non receptor type 7, PTPN 7, PTPNI, Tyrosine protein phosphatase non receptor type 7, PTN7_HUMAN.

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].

Gene ID: 5778