SUV39H2 antibody (AA 201-410)

Catalog No. ABIN7155529

This anti-SUV39H2 antibody is a Rabbit Polyclonal antibody detecting SUV39H2 in WB, ELISA and IHC. Suitable for Human.

Quick Overview for SUV39H2 antibody (AA 201-410) (ABIN7155529)

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV39H2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SUV39H2 Antibody

Binding Specificity: AA 201-410

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Histone-lysine N-methyltransferase SUV39H2 protein (201-410AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SUV39H2

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Alternative Name: SUV39H2

Background:

Background: Histone methyltransferase that specifically trimethylates \\\'Lys-9\\\' of histone H3 using monomethylated H3 \\\'Lys-9\\\' as substrate. H3 \\\'Lys-9\\\' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 \\\'Lys-9\\\' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 \\\'Lys-9\\\' trimethylation.

Aliases: FLJ23414 antibody, H3 K9 HMTase 2 antibody, H3-K9-HMTase 2 antibody, Histone H3 K9 methyltransferase 2 antibody, Histone H3-K9 methyltransferase 2 antibody, Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody, Histone lysine N methyltransferase SUV39H2 antibody, Histone-lysine N-methyltransferase SUV39H2 antibody, KMT1B antibody, Lysine N methyltransferase 1B antibody, Lysine N-methyltransferase 1B antibody, sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody, Su(var)3 9 Drosophila homolog of 2 antibody, Su(var)3 9 homolog 2 antibody, Su(var)3-9 homolog 2 antibody, Suppressor of variegation 3 9 homolog 2 antibody, Suppressor of variegation 3-9 homolog 2 antibody, Suv39h2 antibody, SUV92_HUMAN antibody

UniProt: Q9H5I1