MAML1 antibody (AA 1-45)

Catalog No. ABIN7159033

This anti-MAML1 antibody is a Rabbit Polyclonal antibody detecting MAML1 in ELISA and IHC. Suitable for Human.

Quick Overview for MAML1 antibody (AA 1-45) (ABIN7159033)

Target: MAML1 (Mastermind-Like 1 (MAML1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAML1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-MAML1 Antibody

Binding Specificity: AA 1-45

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mastermind-like protein 1 protein (1-45AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAML1

Target: MAML1 (Mastermind-Like 1 (MAML1))

Alternative Name: MAML1

Background:

Background: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Aliases: Mam-1 antibody, Mam1 antibody, MAML 1 antibody, Maml1 antibody, MAML1_HUMAN antibody, Mastermind like 1 antibody, Mastermind-like protein 1 antibody

UniProt: Q92585

Pathways: Notch Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development