MBTPS1 antibody (AA 187-400)

Catalog No. ABIN7159372

This anti-MBTPS1 antibody is a Rabbit Polyclonal antibody detecting MBTPS1 in ELISA and IHC. Suitable for Human.

Quick Overview for MBTPS1 antibody (AA 187-400) (ABIN7159372)

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBTPS1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-MBTPS1 Antibody

Binding Specificity: AA 187-400

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Membrane-bound transcription factor site-1 protease protein (187-400aa)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MBTPS1

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Alternative Name: MBTPS1

Background:

Background: Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Aliases: Membrane-bound transcription factor site-1 protease (EC 3.4.21.112) (Endopeptidase S1P) (Subtilisin/kexin-isozyme 1) (SKI-1), MBTPS1, KIAA0091 S1P SKI1

UniProt: Q14703

Pathways: ER-Nucleus Signaling