NADPH Oxidase 4 antibody (AA 210-424) (Biotin)

Catalog No. ABIN7161011

This Rabbit Polyclonal antibody specifically detects NADPH Oxidase 4 in ELISA. It exhibits reactivity toward Human.

Quick Overview for NADPH Oxidase 4 antibody (AA 210-424) (Biotin) (ABIN7161011)

Target: NADPH Oxidase 4 (NOX4)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NADPH Oxidase 4 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-NADPH Oxidase 4 Antibody (Biotin)

Binding Specificity: AA 210-424

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human NADPH oxidase 4 protein (210-424AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NADPH Oxidase 4

Target: NADPH Oxidase 4 (NOX4)

Alternative Name: NOX4

Background:

Background: Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.

Aliases: Kidney oxidase 1 antibody, Kidney oxidase-1 antibody, Kidney superoxide producing NADPH oxidase antibody, Kidney superoxide-producing NADPH oxidase antibody, KOX 1 antibody, KOX antibody, Kox-1 antibody, KOX1 antibody, NADPH antibody, NADPH oxidase 4 antibody, Nox4 antibody, NOX4_HUMAN antibody, Renal NAD(P)H oxidase antibody, Renal NAD(P)H-oxidase antibody, RENOX antibody

UniProt: Q9NPH5

Pathways: Carbohydrate Homeostasis, Smooth Muscle Cell Migration