UBA3 antibody (Catalytic Subunit)

Catalog No. ABIN7161136

Product Details anti-UBA3 Antibody

Target: UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))

Binding Specificity: AA 234-463, Catalytic Subunit

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBA3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human NEDD8-activating enzyme E1 catalytic subunit protein (234-463AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBA3

Target: UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))

Alternative Name: UBA3 (UBA3 Products)

Synonyms: UBE1C antibody, hUBA3 antibody, Ube1c antibody, ube1c antibody, wu:fb75e04 antibody, wu:fc37b11 antibody, zgc:55528 antibody, A830034N06Rik antibody, AI256736 antibody, AI848246 antibody, AW546539 antibody, ubiquitin like modifier activating enzyme 3 antibody, ubiquitin-like modifier activating enzyme 3 antibody, ubiquitin like modifier activating enzyme 3 S homeolog antibody, UBA3 antibody, Uba3 antibody, uba3 antibody, uba3.S antibody

Background:

Background: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.

Aliases: DKFZp566J164 antibody, EC 6.3.2. antibody, hUba3 antibody, MGC22384 antibody, NEDD8 activating enzyme E1 catalytic subunit antibody, NEDD8 activating enzyme E1C antibody, Nedd8 activating enzyme hUba3 antibody, NEDD8-activating enzyme E1 catalytic subunit antibody, NEDD8-activating enzyme E1C antibody, uba3 antibody, UBA3 ubiquitin activating enzyme E1 homolog antibody, UBA3_HUMAN antibody, UBE1C antibody, Ubiquitin activating enzyme 3 antibody, Ubiquitin activating enzyme E1C antibody, Ubiquitin-activating enzyme 3 antibody, Ubiquitin-activating enzyme E1C antibody, Ubiquitin-like modifier-activating enzyme 3 antibody

UniProt: Q8TBC4