Nischarin antibody (AA 500-700)

Catalog No. ABIN7161622

This anti-Nischarin antibody is a Rabbit Polyclonal antibody detecting Nischarin in IHC and ELISA. Suitable for Human.

Quick Overview for Nischarin antibody (AA 500-700) (ABIN7161622)

Target: Nischarin (NISCH)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nischarin antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-Nischarin Antibody

Binding Specificity: AA 500-700

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Nischarin protein (500-700AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Nischarin

Target: Nischarin (NISCH)

Alternative Name: NISCH

Background:

Background: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 \\\'Tyr-508\\\' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.

Aliases: NISCH antibody, IRAS antibody, KIAA0975 antibody, Nischarin antibody, Imidazoline receptor 1 antibody, I-1 antibody, IR1 antibody, Imidazoline receptor antisera-selected protein antibody, hIRAS antibody, Imidazoline-1 receptor antibody, I1R antibody, Imidazoline-1 receptor candidate protein antibody, I-1 receptor candidate protein antibody, I1R candidate protein antibody

UniProt: Q9Y2I1