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NUAK1 antibody (AA 442-573) (FITC)

NUAK1 Reactivity: Human Host: Rabbit Polyclonal FITC
Catalog No. ABIN7161744
  • Target See all NUAK1 Antibodies
    NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
    Binding Specificity
    • 15
    • 8
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 442-573
    Reactivity
    • 56
    • 27
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 52
    • 4
    • 1
    Rabbit
    Clonality
    • 56
    • 1
    Polyclonal
    Conjugate
    • 23
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NUAK1 antibody is conjugated to FITC
    Application
    Please inquire
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human NUAK family SNF1-like kinase 1 protein (442-573AA)
    Isotype
    IgG
    Top Product
    Discover our top product NUAK1 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
    Alternative Name
    NUAK1 (NUAK1 Products)
    Synonyms
    ARK5 antibody, AU014801 antibody, AW494241 antibody, B230104P22Rik antibody, Omphk1 antibody, NUAK family kinase 1 antibody, NUAK family, SNF1-like kinase, 1 antibody, NUAK1 antibody, Nuak1 antibody
    Background

    Background: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of \'Ser-464\' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at \'Ser-15\' and \'Ser-392\' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).

    Aliases: NUAK1 antibody, ARK5 antibody, KIAA0537 antibody, OMPHK1 antibody, NUAK family SNF1-like kinase 1 antibody, EC 2.7.11.1 antibody, AMPK-related protein kinase 5 antibody, ARK5 antibody, Omphalocele kinase 1 antibody

    UniProt
    O60285
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