PPID antibody (AA 161-370)

Catalog No. ABIN7162803

Product Details anti-PPID Antibody

Target: PPID (Peptidylprolyl Isomerase D (PPID))

Binding Specificity: AA 161-370

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPID antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Peptidyl-prolyl cis-trans isomerase D protein (161-370AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PPID

Target: PPID (Peptidylprolyl Isomerase D (PPID))

Alternative Name: PPID (PPID Products)

Synonyms: PPID antibody, CYP-40 antibody, CYPD antibody, Cyp-40 antibody, CypD antibody, wu:fb18b07 antibody, zgc:86711 antibody, 4930564J03Rik antibody, Ppidl antibody, Ppif antibody, cyp-40 antibody, cypd antibody, peptidylprolyl isomerase D antibody, peptidylprolyl isomerase D (cyclophilin D) antibody, peptidylprolyl isomerase D (cyclophilin D) S homeolog antibody, PPID antibody, Ppid antibody, ppid antibody, ppid.S antibody

Background:

Background: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer, the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

Aliases: 40 kDa peptidyl-prolyl cis-trans isomerase antibody, 40 kDa peptidyl-prolyl cis-trans isomerase D antibody, Cyclophilin related protein antibody, Cyclophilin-40 antibody, Cyclophilin-related protein antibody, CYP-40 antibody, CYP40 antibody, CYPD antibody, Estrogen receptor-binding cyclophilin antibody, Peptidyl-prolyl cis-trans isomerase D antibody, Peptidylprolyl isomerase D antibody, PPIase D antibody, Ppid antibody, PPID_HUMAN antibody, Rotamase antibody, Rotamase D antibody

UniProt: Q08752

Pathways: Nuclear Hormone Receptor Binding