Presenilin 1 antibody (AA 4-218)

Catalog No. ABIN7164264

The Rabbit Polyclonal anti-Presenilin 1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect Presenilin 1 in samples from Human.

Quick Overview for Presenilin 1 antibody (AA 4-218) (ABIN7164264)

Target: Presenilin 1 (PSEN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Presenilin 1 Antibody

Binding Specificity: AA 4-218

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Presenilin-1 protein (4-218AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:2000-1:10000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Presenilin 1

Target: Presenilin 1 (PSEN1)

Alternative Name: PSEN1

Background:

Background: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Aliases: AD3 antibody, Ad3h antibody, FAD antibody, Homo Sapiens Clone CC44 Senilin 1 antibody, Presenilin-1 CTF12 antibody, Protein S182 antibody, PS 1 antibody, PS-1 antibody, PS1-CTF12 antibody, PSEN1 antibody, PSN1_HUMAN antibody, PSNL1 antibody, S182 antibody

UniProt: P49768

Pathways: Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport