PSME4 antibody (AA 105-198) (FITC)

Catalog No. ABIN7164925

The FITC-conjugated Rabbit Polyclonal anti-PSME4 antibody (ABIN7164925) specifically detects PSME4. The antibody is reactive with Human samples.

Quick Overview for PSME4 antibody (AA 105-198) (FITC) (ABIN7164925)

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSME4 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-PSME4 Antibody (FITC)

Binding Specificity: AA 105-198

Purpose: PSME4 Antibody, FITC conjugated

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Proteasome activator complex subunit 4 protein (105-198AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSME4

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Alternative Name: PSME4

Background:

Background: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Aliases: KIAA0077 antibody, PA200 antibody, Proteasome Activator 200 kDa antibody, Proteasome activator complex subunit 4 antibody, Proteasome activator PA200 antibody, PSME 4 antibody, psme4 antibody, PSME4_HUMAN antibody

UniProt: Q14997

Pathways: DNA Replication, Synthesis of DNA