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MEFV antibody (AA 268-374) (HRP)

MEFV Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7166887
  • Target See all MEFV Antibodies
    MEFV (Mediterranean Fever (MEFV))
    Binding Specificity
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 268-374
    Reactivity
    • 22
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 19
    • 2
    • 1
    Rabbit
    Clonality
    • 21
    • 1
    Polyclonal
    Conjugate
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    This MEFV antibody is conjugated to HRP
    Application
    • 18
    • 14
    • 2
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Pyrin protein (268-374AA)
    Isotype
    IgG
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  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    MEFV (Mediterranean Fever (MEFV))
    Alternative Name
    MEFV (MEFV Products)
    Synonyms
    pyrin antibody, MEFV antibody, FMF antibody, MEF antibody, TRIM20 antibody, rfp domain antibody, MEFV, pyrin innate immunity regulator antibody, Mediterranean fever antibody, MEFV antibody, Mefv antibody
    Background

    Background: Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed:16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed:10807793, PubMed:11468188, PubMed:17964261, PubMed:18577712, PubMed:19109554, PubMed:19584923).

    Aliases: FMF antibody, Marenostrin antibody, Mediterranean fever antibody, Mediterranean fever protein antibody, MEF antibody, Mefv antibody, MEFV_HUMAN antibody, Pyrin antibody, TRIM20 antibody

    UniProt
    O15553
    Pathways
    Positive Regulation of Endopeptidase Activity
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