UPF3B antibody (AA 319-423)

Catalog No. ABIN7167644

This Rabbit Polyclonal antibody specifically detects UPF3B in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for UPF3B antibody (AA 319-423) (ABIN7167644)

Target: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UPF3B antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-UPF3B Antibody

Binding Specificity: AA 319-423

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Regulator of nonsense transcripts 3B protein (319-423AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UPF3B

Target: UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))

Alternative Name: UPF3B

Background:

Background: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation, the function is independent of association with UPF2 and components of the EJC core.

Aliases: UPF3B antibody, RENT3B antibody, UPF3X antibody, Regulator of nonsense transcripts 3B antibody, Nonsense mRNA reducing factor 3B antibody, Up-frameshift suppressor 3 homolog B antibody, hUpf3B antibody, Up-frameshift suppressor 3 homolog on chromosome X antibody, hUpf3p-X antibody

UniProt: Q9BZI7