CoREST antibody (AA 394-482) (HRP)

Catalog No. ABIN7167724

This anti-CoREST antibody is a Rabbit Polyclonal antibody detecting CoREST in ELISA. Suitable for Human.

Quick Overview for CoREST antibody (AA 394-482) (HRP) (ABIN7167724)

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CoREST antibody is conjugated to HRP

Application: ELISA

Product Details anti-CoREST Antibody (HRP)

Binding Specificity: AA 394-482

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human REST corepressor 1 protein (394-482AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CoREST

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Alternative Name: RCOR1

Background:

Background: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Aliases: COREST antibody, KIAA0071 antibody, Nr2b2 antibody, Nuclear receptor coregulator 1 antibody, Nuclear receptor subfamily 2 group B member 2 antibody, Protein CoREST antibody, RCOR antibody, Rcor1 antibody, RCOR1_HUMAN antibody, REST corepressor 1 antibody, Retinoic acid receptor RXR-beta antibody, Retinoid X receptor beta antibody, Rxrb antibody

UniProt: Q9UKL0

Pathways: Regulation of Hormone Metabolic Process, Chromatin Binding