MARK1 antibody (AA 560-700)

Catalog No. ABIN7169067

The Rabbit Polyclonal anti-MARK1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect MARK1 in samples from Human.

Quick Overview for MARK1 antibody (AA 560-700) (ABIN7169067)

Target: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MARK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MARK1 Antibody

Binding Specificity: AA 560-700

Cross-Reactivity: Human, Rat

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Serine/threonine-protein kinase MARK1 protein (560-700AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MARK1

Target: MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))

Alternative Name: MARK1

Background:

Background: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

Aliases: KIAA1477 antibody, MAP/microtubule affinity regulating kinase 1 antibody, MAP/microtubule affinity-regulating kinase 1 antibody, MARK 1 antibody, MARK antibody, Mark1 antibody, MARK1_HUMAN antibody, MGC126512 antibody, MGC126513 antibody, Serine/threonine protein kinase MARK1 antibody, Serine/threonine-protein kinase MARK1 antibody

UniProt: Q9P0L2

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection