PINK1 antibody (AA 162-272)

Catalog No. ABIN7169153

This Rabbit Polyclonal antibody specifically detects PINK1 in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for PINK1 antibody (AA 162-272) (ABIN7169153)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PINK1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-PINK1 Antibody

Binding Specificity: AA 162-272

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase PINK1, mitochondrial protein (162-272AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Alternative Name: PINK1

Background:

Background: Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at \\\'Ser-65\\\' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291).

Aliases: BRPK antibody, FLJ27236 antibody, mitochondrial antibody, PARK 6 antibody, PARK6 antibody, Phosphatase and Tensin Homolog antibody, PINK 1 antibody, PINK1 antibody, PINK1_HUMAN antibody, Protein kinase BRPK antibody, PTEN induced putative kinase 1 antibody, PTEN induced putative kinase protein 1 antibody, PTEN-induced putative kinase protein 1 antibody, Serine/threonine kinase PINK1 mitochondrial antibody, Serine/threonine protein kinase PINK1 mitochondrial antibody, Serine/threonine-protein kinase PINK1 antibody

UniProt: Q9BXM7

Pathways: Autophagy