PLK2 antibody (AA 336-685)

Catalog No. ABIN7169161

This anti-PLK2 antibody is a Rabbit Polyclonal antibody detecting PLK2 in ELISA and IHC. Suitable for Human.

Quick Overview for PLK2 antibody (AA 336-685) (ABIN7169161)

Target: PLK2 (Polo-Like Kinase 2 (PLK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLK2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-PLK2 Antibody

Binding Specificity: AA 336-685

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Serine/threonine-protein kinase PLK2 protein (336-685AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PLK2

Target: PLK2 (Polo-Like Kinase 2 (PLK2))

Alternative Name: PLK2

Background:

Background: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.

Aliases: hPlk2 antibody, hSNK antibody, PLK-2 antibody, Plk2 antibody, PLK2_HUMAN antibody, Polo like kinase 2 antibody, Polo-like kinase 2 antibody, Serine/threonine protein kinase PLK2 antibody, Serine/threonine protein kinase SNK antibody, Serine/threonine-protein kinase PLK2 antibody, Serine/threonine-protein kinase SNK antibody, Serum Induced Kinase antibody, Serum-inducible kinase antibody, SNK antibody

UniProt: Q9NYY3