PLK3 antibody (AA 487-646)

Catalog No. ABIN7169162

This Rabbit Polyclonal antibody specifically detects PLK3 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for PLK3 antibody (AA 487-646) (ABIN7169162)

Target: PLK3 (Polo-Like Kinase 3 (PLK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLK3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PLK3 Antibody

Binding Specificity: AA 487-646

Cross-Reactivity: Human, Rat

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Serine/threonine-protein kinase PLK3 protein (487-646AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PLK3

Target: PLK3 (Polo-Like Kinase 3 (PLK3))

Alternative Name: PLK3

Background:

Background: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.

Aliases: CNK antibody, Cytokine Inducible Kinase antibody, Cytokine-inducible serine/threonine-protein kinase antibody, FGF inducible kinase antibody, FGF-inducible kinase antibody, FNK antibody, PLK-3 antibody, Plk3 antibody, PLK3_HUMAN antibody, Polo Like Kinase 3 antibody, Polo-like kinase 3 antibody, PRK antibody, Proliferation Related Kinase antibody, Proliferation-related kinase antibody, Serine/threonine-protein kinase PLK3 antibody

UniProt: Q9H4B4

Pathways: Regulation of long-term Neuronal Synaptic Plasticity