SOCS5 antibody (AA 1-270)

Catalog No. ABIN7171007

This Rabbit Polyclonal antibody specifically detects SOCS5 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for SOCS5 antibody (AA 1-270) (ABIN7171007)

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SOCS5 Antibody

Binding Specificity: AA 1-270

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 5 protein (1-270AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SOCS5

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Alternative Name: SOCS5

Background:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Aliases: SOCS5 antibody, CIS6 antibody, CISH5 antibody, CISH6 antibody, KIAA0671Suppressor of cytokine signaling 5 antibody, SOCS-5 antibody, Cytokine-inducible SH2 protein 6 antibody, CIS-6 antibody, Cytokine-inducible SH2-containing protein 5 antibody

UniProt: O75159

Pathways: JAK-STAT Signaling, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process