TRF1 antibody (AA 260-439) (Biotin)

Catalog No. ABIN7171730

This Rabbit Polyclonal antibody specifically detects TRF1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for TRF1 antibody (AA 260-439) (Biotin) (ABIN7171730)

Target: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRF1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-TRF1 Antibody (Biotin)

Binding Specificity: AA 260-439

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Telomeric repeat-binding factor 1 protein (260-439AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRF1

Target: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Alternative Name: TERF1

Background:

Background: Binds the telomeric double-stranded 5\'-TTAGGG-3\' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5\'-TTAGGG-3\' repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.

Aliases: hTRF1 AS antibody, NIMA interacting protein 2 antibody, NIMA-interacting protein 2 antibody, PIN 2 antibody, PIN2 antibody, t TRF1 antibody, Telomeric protein Pin2 antibody, Telomeric protein Pin2/TRF1 antibody, Telomeric repeat binding factor (NIMA interacting) 1 antibody, Telomeric repeat binding factor 1 antibody, Telomeric repeat binding protein 1 antibody, Telomeric repeat-binding factor 1 antibody, TERF 1 antibody, Terf1 antibody, TERF1_HUMAN antibody, TRBF 1 antibody, TRBF1 antibody, TRF 1 antibody, TRF antibody, TTAGGG repeat binding factor 1 antibody, TTAGGG repeat-binding factor 1 antibody

UniProt: P54274

Pathways: Cell Division Cycle, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity