TSPAN12 antibody (AA 111-224) (Biotin)

Catalog No. ABIN7171847

This Rabbit Polyclonal antibody specifically detects TSPAN12 in ELISA. It exhibits reactivity toward Human.

Quick Overview for TSPAN12 antibody (AA 111-224) (Biotin) (ABIN7171847)

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSPAN12 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-TSPAN12 Antibody (Biotin)

Binding Specificity: AA 111-224

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Tetraspanin-12 protein (111-224AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TSPAN12

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Alternative Name: TSPAN12

Background:

Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Aliases: TSPAN12 antibody, NET2 antibody, TM4SF12 antibody, UNQ774/PRO1568Tetraspanin-12 antibody, Tspan-12 antibody, Tetraspan NET-2 antibody, Transmembrane 4 superfamily member 12 antibody

UniProt: O95859