TICAM2 antibody (AA 1-235)

Catalog No. ABIN7172205

Product Details anti-TICAM2 Antibody

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Binding Specificity: AA 1-235

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TICAM2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human TIR domain-containing adapter molecule 2 protein (1-235AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TICAM2

Target: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Alternative Name: TICAM2 (TICAM2 Products)

Synonyms: MyD88-4 antibody, TICAM-2 antibody, TIRAP3 antibody, TIRP antibody, TRAM antibody, B430113A10 antibody, Tirp antibody, Trif antibody, toll like receptor adaptor molecule 2 antibody, toll-like receptor adaptor molecule 2 antibody, TICAM2 antibody, Ticam2 antibody

Background:

Background: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1, signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB, however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

Aliases: Putative NF-kappa-B-activating protein 502 antibody, TCAM2_HUMAN antibody, TICAM-2 antibody, TICAM2 antibody, TIR containing adapter molecule 2 antibody, TIR domain containing adaptor protein antibody, TIR domain-containing adapter molecule 2 antibody, TIRAP 3 antibody, TIRAP3 antibody, TIRAP3a short form antibody, TIRP antibody, Toll-like receptor adaptor protein 3 antibody, Toll/interleukin-1 receptor domain-containing protein antibody, TRAM antibody, TRIF-related adapter molecule antibody

UniProt: Q86XR7

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades