P4HTM antibody (AA 82-563) (Biotin)

Catalog No. ABIN7173000

Product Details anti-P4HTM Antibody (Biotin)

Target: P4HTM (Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum) (P4HTM))

Binding Specificity: AA 82-563

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P4HTM antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transmembrane prolyl 4-hydroxylase protein (82-563AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for P4HTM

Target: P4HTM (Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum) (P4HTM))

Alternative Name: P4HTM (P4HTM Products)

Synonyms: Ph-4 antibody, RGD1311848 antibody, EGLN4 antibody, HIFPH4 antibody, P4H-TM antibody, PH-4 antibody, PH4 antibody, PHD4 antibody, 4933406E20Rik antibody, AI853847 antibody, BB128974 antibody, prolyl 4-hydroxylase, transmembrane antibody, prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) antibody, shisa family member 5 antibody, P4htm antibody, P4HTM antibody, SHISA5 antibody

Background:

Background: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at \'Pro-402\' and \'Pro-564\'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

Aliases: EGLN4 antibody, HIF PH4 antibody, HIF Prolyl Hydroxylase 4 antibody, HIF prolyl hydroxylase PH 4 antibody, HIF prolyl hydroxylase PH4 antibody, HIF-PH4 antibody, HIF-prolyl hydroxylase 4 antibody, HIFPH4 antibody, HPH 4 antibody, HPH-4 antibody, Hypoxia inducible factor prolyl 4 hydroxylase antibody, Hypoxia-inducible factor prolyl hydroxylase 4 antibody, P4H with transmembrane domain antibody, P4H-TM antibody, P4htm antibody, P4HTM_HUMAN antibody, PH 4 antibody, PH4 antibody, PHD 4 antibody, Proline 4 hydroxylase antibody, prolyl 4-hydroxylase antibody, Transmembrane prolyl 4-hydroxylase antibody

UniProt: Q9NXG6