P4HTM antibody (C-Term)

Catalog No. ABIN7449275

The Rabbit Polyclonal anti-P4HTM antibody is suitable to detect P4HTM in samples from Human. It has been validated for WB.

Quick Overview for P4HTM antibody (C-Term) (ABIN7449275)

Target: P4HTM (Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum) (P4HTM))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P4HTM antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-P4HTM Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-PHD4 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 450 and C-term

Isotype: IgG

Application Details

Application Notes: 1:500 - 1:2,500

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for P4HTM

Target: P4HTM (Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum) (P4HTM))

Alternative Name: PHD4

Background: Background: PHD4 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.

Gene ID: 54681

NCBI Accession: NP_808808

UniProt: Q9NXG6