CSK antibody (AA 325-416) (Biotin)

Catalog No. ABIN7174016

This Rabbit Polyclonal antibody specifically detects CSK in ELISA. It exhibits reactivity toward Human.

Quick Overview for CSK antibody (AA 325-416) (Biotin) (ABIN7174016)

Target: CSK (C-Src tyrosine Kinase (CSK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSK antibody is conjugated to Biotin

Application: ELISA

Product Details anti-CSK Antibody (Biotin)

Binding Specificity: AA 325-416

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Tyrosine-protein kinase CSK protein (325-416AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CSK

Target: CSK (C-Src tyrosine Kinase (CSK))

Alternative Name: CSK

Background:

Background: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Aliases: C SRC antibody, C SRC kinase antibody, C src Tyrosine Kinase antibody, C-SRC kinase antibody, c-src tyrosine kinase antibody, Csk A antibody, CSK antibody, CSK_HUMAN antibody, CYTOPLASMIC TYROSINE KINASE antibody, EC 2.7.10.2 antibody, MGC112926 antibody, MGC117393 antibody, MGC154049 antibody, P60 Src antibody, Protein tyrosine kinase CYL antibody, Protein-tyrosine kinase CYL antibody, Proto oncogene tyrosine protein kinase antibody, Tyrosine protein kinase CSK antibody, Tyrosine-protein kinase CSK antibody, zgc:154049 antibody

UniProt: P41240

Pathways: TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events