USP37 antibody (AA 671-797) (Biotin)

Catalog No. ABIN7174325

This Rabbit Polyclonal antibody specifically detects USP37 in ELISA. It exhibits reactivity toward Human.

Quick Overview for USP37 antibody (AA 671-797) (Biotin) (ABIN7174325)

Target: USP37 (Ubiquitin Specific Peptidase 37 (USP37))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP37 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-USP37 Antibody (Biotin)

Binding Specificity: AA 671-797

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 37 protein (671-797AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for USP37

Target: USP37 (Ubiquitin Specific Peptidase 37 (USP37))

Alternative Name: USP37

Background:

Background: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of \'Lys-11\'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of \'Lys-48\'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).

Aliases: Deubiquitinating enzyme 3 antibody, Deubiquitinating enzyme 37 antibody, EC 3.1.2.15 antibody, KIAA1594 antibody, MGC117261 antibody, OTTHUMP00000164146 antibody, tmp_locus_50 antibody, Ubiquitin carboxyl-terminal hydrolase 37 antibody, Ubiquitin specific peptidase 37 antibody, Ubiquitin specific processing protease 37 antibody, Ubiquitin specific protease 37 antibody, Ubiquitin thioesterase 37 antibody, Ubiquitin thiolesterase 37 antibody, Ubiquitin-specific-processing protease 37 antibody, UBP37_HUMAN antibody, USP37 antibody

UniProt: Q86T82