Villin 1 antibody (AA 1-350)
-
- Target See all Villin 1 (VIL1) Antibodies
- Villin 1 (VIL1)
-
Binding Specificity
- AA 1-350
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This Villin 1 antibody is un-conjugated
-
Application
- Immunohistochemistry (IHC), ELISA
- Cross-Reactivity
- Human
- Purification
- Antigen Affinity Purified
- Immunogen
- Recombinant Human Villin-1 protein (1-350AA)
- Isotype
- IgG
- Top Product
- Discover our top product VIL1 Primary Antibody
-
-
- Application Notes
- Recommended dilution: IHC:1:20-1:200,
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
- Target
- Villin 1 (VIL1)
- Alternative Name
- VIL1 (VIL1 Products)
- Synonyms
- D2S1471 antibody, VIL antibody, Vil antibody, vil1 antibody, MGC64339 antibody, VIL1 antibody, vil1l antibody, zgc:55779 antibody, villin 1 antibody, villin 1 S homeolog antibody, VIL1 antibody, Vil1 antibody, vil1.S antibody, vil1 antibody
- Background
-
Background: Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA), binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.
Aliases: D2S1471 antibody, OTTHUMP00000164145 antibody, VIL antibody, VIL1 antibody, VILI_HUMAN antibody, Villin 1 antibody, Villin-1 antibody, Villin1 antibody
- UniProt
- P09327
- Pathways
- EGFR Signaling Pathway, Regulation of Actin Filament Polymerization
-