KEAP1 antibody (AA 1-624) (Biotin)

Catalog No. ABIN7177370

This Rabbit Polyclonal antibody specifically detects KEAP1 in ELISA. It exhibits reactivity toward Mouse.

Quick Overview for KEAP1 antibody (AA 1-624) (Biotin) (ABIN7177370)

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KEAP1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-KEAP1 Antibody (Biotin)

Binding Specificity: AA 1-624

Cross-Reactivity: Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse Kelch-like ECH-associated protein 1 protein (1-624AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Alternative Name: Keap1

Background:

Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).

Aliases: Keap1 antibody, Inrf2 antibody, Kiaa0132Kelch-like ECH-associated protein 1 antibody, Cytosolic inhibitor of Nrf2 antibody, INrf2 antibody

UniProt: Q9Z2X8

Pathways: Maintenance of Protein Location