Perforin 1 antibody (AA 21-554)

Catalog No. ABIN7177734

The Rabbit Polyclonal anti-Perforin 1 antibody has been validated for WB, ELISA and IF. It is suitable to detect Perforin 1 in samples from Mouse.

Quick Overview for Perforin 1 antibody (AA 21-554) (ABIN7177734)

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Perforin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-Perforin 1 Antibody

Binding Specificity: AA 21-554

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse Perforin-1 protein (21-554AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Perforin 1

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Alternative Name: Prf1

Background:

Background: Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.

Aliases: Prf1 antibody, Pfp antibody, Perforin-1 antibody, P1 antibody, Cytolysin antibody, Lymphocyte pore-forming protein antibody

UniProt: P10820

Pathways: Apoptosis, Caspase Cascade in Apoptosis