TXNIP antibody (AA 1-397) (HRP)

Catalog No. ABIN7177898

This Rabbit Polyclonal antibody specifically detects TXNIP in ELISA. It exhibits reactivity toward Mouse.

Quick Overview for TXNIP antibody (AA 1-397) (HRP) (ABIN7177898)

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNIP antibody is conjugated to HRP

Application: ELISA

Product Details anti-TXNIP Antibody (HRP)

Binding Specificity: AA 1-397

Cross-Reactivity: Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Mouse Thioredoxin-interacting protein (1-397AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Alternative Name: Txnip

Background:

Background: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.

Aliases: Txnip antibody, Vdup1 antibody, Thioredoxin-interacting protein antibody, Vitamin D3 up-regulated protein 1 antibody

UniProt: Q8BG60

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome