CD11b antibody (PE)

Catalog No. ABIN7178496

The Mouse Monoclonal anti-CD11b antibody has been validated for FACS, IF and ELISA. It is suitable to detect CD11b in samples from Human.

Quick Overview for CD11b antibody (PE) (ABIN7178496)

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD11b antibody is conjugated to PE

Application: Flow Cytometry (FACS), Immunofluorescence (IF), ELISA

Product Details anti-CD11b Antibody (PE)

Cross-Reactivity: Human

Purification: Affinity purified

Immunogen: Recombinant Protein

Isotype: IgG1, IgG1 kappa

Application Details

Application Notes: Recommended dilution:IF:1:100-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered solution, pH 7.4, containing 0.09 % sodium azide and 0.2 % (w/v) BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name: ITGAM

Background:

Background: 4AM216 reacts with CD11b, a member of the integrin a chain family with 165 kDa MW. which is expressed on NK cells, monocytes, granulocytes and subsets of T and B cells. It associates with CD18 to form CD11b/CD18 complex .The cellular function of CD11b is on neutrophil and monocyte interactions with stimulated endothelium; Phagocytosis of iC3b or IgG coated particles as a receptor; Chemotaxis and apoptosis.* CD11b is absent in Leukocyte Adhesion Deficiency (LAD-1) patients who have major problems with bacterial infections.This clone is cross reactive with non-human primate.1. Ling NR  et al., eds. (1987) Leucocyte Typing  III : White Cell Differentiation Antigens, Oxford University Press, New York. 303-3342. Petty HR nd Todd RF. (1996) Immunol. Today 17:2093. Springer TA (1994) Cell 76:3014. Stewart M et al (1995) Curr Opin Cell Biol 7:690

Aliases: N/A

UniProt: P11215

Pathways: Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation