SOCS3 antibody (AA 1-225) (Biotin)

Catalog No. ABIN7179082

This anti-SOCS3 antibody is a Rabbit Polyclonal antibody detecting SOCS3 in ELISA. Suitable for Rat.

Quick Overview for SOCS3 antibody (AA 1-225) (Biotin) (ABIN7179082)

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-SOCS3 Antibody (Biotin)

Binding Specificity: AA 1-225

Cross-Reactivity: Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Rat Suppressor of cytokine signaling 3 protein (1-225AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Alternative Name: Socs3

Background:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Aliases: Socs3 antibody, Cish3Suppressor of cytokine signaling 3 antibody, SOCS-3 antibody, Cytokine-inducible SH2 protein 3 antibody

UniProt: O88583

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C