Dynamin 1-Like antibody (C-Term)

Catalog No. ABIN7180161

The Rabbit Polyclonal anti-Dynamin 1-Like antibody has been validated for WB and ELISA. It is suitable to detect Dynamin 1-Like in samples from Human.

Quick Overview for Dynamin 1-Like antibody (C-Term) (ABIN7180161)

Target: Dynamin 1-Like (DNM1L)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamin 1-Like antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Dynamin 1-Like Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human DNM1L.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Alternative Name: DNM1L

Background:

Background: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L)which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.

Shin H.-W., J. Biochem. 122:525-530(1997).
Hong Y.-R., Biochem. Biophys. Res. Commun. 249:697-703(1998).
Imoto M., J. Cell Sci. 111:1341-1349(1998).

Aliases: DLP1 antibody, dnm1l antibody, DNM1L_HUMAN antibody, Dnm1p/Vps1p-like protein antibody, dnml1 antibody, DRP1 antibody, DVLP antibody, Dymple antibody, Dynamin 1 like antibody, Dynamin family member proline-rich carboxyl-terminal domain less antibody, Dynamin like protein antibody, Dynamin related protein 1 antibody, Dynamin-1-like protein antibody, Dynamin-like protein 4 antibody, Dynamin-like protein antibody, Dynamin-like protein IV antibody, Dynamin-related protein 1 antibody, DYNIV 11 antibody, EMPF antibody, EMPF1 antibody, FLJ41912 antibody, HdynIV antibody, VPS1 antibody

UniProt: O00429