GNE antibody (C-Term)

Catalog No. ABIN7180179

The Rabbit Polyclonal anti-GNE antibody is suitable to detect GNE in samples from Human. It has been validated for WB, IHC and ELISA.

Quick Overview for GNE antibody (C-Term) (ABIN7180179)

Target: GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNE antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-GNE Antibody

Binding Specificity: C-Term

Purpose: GNE Antibody

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human GNE.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GNE

Target: GNE (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE))

Alternative Name: GNE

Background:

Background: Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development By similarity. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.

Lucka L., FEBS Lett. 454:341-344(1999).
Seppala R., Am. J. Hum. Genet. 64:1563-1569(1999).
Huizing M., Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.

Aliases: 2310066H07Rik antibody, Bifunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase antibody, DMRV antibody, GLCNE_HUMAN antibody, Glucosamine (UDP N acetyl) 2 epimerase/N acetylmannosamine kinase antibody, GNE antibody, IBM2 antibody, ManAc kinase antibody, N acylmannosamine kinase antibody, N-acetylmannosamine kinase antibody, NM antibody, RP23-209M8.6 antibody, Uae1 antibody, UDP GlcNAc 2 epimerase antibody, UDP GlcNAc 2 epimerase/ManAc kinase antibody, UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase antibody, UDP-GlcNAc-2-epimerase antibody, UDP-GlcNAc-2-epimerase/ManAc kinase antibody, Uridine diphosphate N acetylglucosamine 2 epimerase antibody, Uridine diphosphate-N-acetylglucosamine-2-epimerase antibody

UniProt: Q9Y223