PAK7 antibody (C-Term)

Catalog No. ABIN7180220

This Rabbit Polyclonal antibody specifically detects PAK7 in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for PAK7 antibody (C-Term) (ABIN7180220)

Target: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PAK7 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human PAK7.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PAK7

Target: PAK7 (P21 Protein (Cdc42/Rac)-Activated Kinase 7 (PAK7))

Alternative Name: PAK5

Background:

Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

Pandey A., Oncogene 21:3939-3948(2002).
Nagase T., DNA Res. 6:337-345(1999).
Deloukas P., Nature 414:865-871(2001).

Aliases: EC 2.7.11.1 antibody, KIAA1264 antibody, MGC26232 antibody, p21 activated kinase 7 antibody, p21 protein (Cdc42/Rac)-activated kinase 7 antibody, p21(CDKN1A) activated kinase 7 antibody, p21-activated kinase 5 antibody, p21-activated kinase 7 antibody, PAK 5 antibody, PAK 7 antibody, PAK-5 antibody, PAK-7 antibody, PAK5 antibody, PAK7 antibody, PAK7_HUMAN antibody, Protein kinase PAK5 antibody, Serine/threonine protein kinase PAK 7 antibody, Serine/threonine-protein kinase PAK 7 antibody

UniProt: Q9P286