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CCAR2 antibody

CCAR2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7183705
  • Target See all CCAR2 Antibodies
    CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
    Reactivity
    • 27
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 17
    • 8
    • 2
    Rabbit
    Clonality
    • 21
    • 6
    Polyclonal
    Conjugate
    • 20
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CCAR2 antibody is un-conjugated
    Application
    • 18
    • 10
    • 10
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity
    Human
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    Immunogen
    Synthesized peptide derived from internal of Human KIAA1967.
    Isotype
    IgG
    Top Product
    Discover our top product CCAR2 Primary Antibody
  • Application Notes
    WB:1:500-1:3000,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
    Alternative Name
    CCAR2 (CCAR2 Products)
    Synonyms
    DBC-1 antibody, DBC1 antibody, KIAA1967 antibody, NET35 antibody, p30 DBC antibody, p30DBC antibody, 2610301G19Rik antibody, mKIAA1967 antibody, RGD1309922 antibody, Kiaa1967 antibody, cell cycle and apoptosis regulator 2 antibody, cell cycle activator and apoptosis regulator 2 antibody, CCAR2 antibody, Ccar2 antibody
    Background

    Background: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.

    Nagase T., DNA Res. 8:319-327(2001).
    Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002).
    Olsen J.V., Cell 127:635-648(2006).

    Aliases: CCAR2 antibody, DBC1 antibody, KIAA1967Cell cycle and apoptosis regulator protein 2 antibody, Cell division cycle and apoptosis regulator protein 2 antibody, DBIRD complex subunit KIAA1967 antibody, Deleted in breast cancer gene 1 protein antibody, DBC-1 antibody, DBC.1 antibody, NET35 antibody, p30 DBC antibody

    UniProt
    Q8N163
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