CCAR2 antibody

Catalog No. ABIN7864161

The Mouse Monoclonal anti-CCAR2 antibody is suitable to detect CCAR2 in samples from Human. It has been validated for IHC and FACS.

Quick Overview for CCAR2 antibody (ABIN7864161)

Target: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCAR2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: PCRP-KIAA1967-1D10

Product Details anti-CCAR2 Antibody

Purpose: KIAA1967 / DBC1 / CCAR2 Antibody

Specificity: DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF±, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNF±-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ER±, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human CCAR2 / KIAA1967 protein

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for CCAR2

Target: CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))

Alternative Name: KIAA1967

Background:

CCAR2, Cell division cycle and apoptosis regulator protein 2, DBC.1, DBC1, DBIRD complex subunit KIAA1967, Deleted in breast cancer gene 1 protein, K1967_HUMAN, KIAA1967, NET35, p30 DBC, p30DBC

Expressed ubiquitously in normal tissues. Expressed in 84 to 100 % of neoplastic breast, lung, and colon tissues.

Molecular Weight: 102.9kDa

Gene ID: 57805, 433722

UniProt: Q8N163