TLR3 antibody (AA 24-217)

Catalog No. ABIN7193368

This Mouse Monoclonal antibody specifically detects TLR3 in ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for TLR3 antibody (AA 24-217) (ABIN7193368)

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLR3 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 6F3G4

Product Details anti-TLR3 Antibody

Binding Specificity: AA 24-217

Purpose: CD283 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD283 (AA: 24-217) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Alternative Name: CD283

Background:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

Molecular Weight: 103.8 kDa

UniProt: O15455

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades