NOXA antibody (AA 1-54)
Quick Overview for NOXA antibody (AA 1-54) (ABIN7193484)
Target
See all NOXA (PMAIP1) AntibodiesReactivity
Host
Clonality
Conjugate
Application
Clone
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Binding Specificity
- AA 1-54
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Purpose
- PMAIP1 Antibody
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Purification
- Purified antibody
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Immunogen
- Purified recombinant fragment of human PMAIP1 (AA: 1-54) expressed in E. Coli.
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Isotype
- IgG1
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anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (AA 1-54) antibody
PMAIP1 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (AA 1-136) antibodyPMAIP1 Reactivity: Human ELISA, IF, IHC Host: Rabbit Polyclonal unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) antibodyPMAIP1 Reactivity: Human WB, IF, IHC, FACS Host: Mouse Monoclonal 114C307-1 unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (Internal Region) antibodyVerified PMAIP1 Reactivity: Human WB, ELISA Host: Goat Polyclonal unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (AA 1-136) antibodyPMAIP1 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) (N-Term) antibodyPMAIP1 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
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Application Notes
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ELISA: 1/10000
FCM: 1/200 - 1/400
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- NOXA (PMAIP1) (Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
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Alternative Name
- PMAIP1
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Background
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The protein encoded by this gene promotes activation of caspases and apoptosis, Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
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Molecular Weight
- 6 kDa
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Gene ID
- 5366
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UniProt
- Q13794
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Pathways
- p53 Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
Target
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