Prosaposin antibody (AA 17-216)

Catalog No. ABIN7193617

This Mouse Monoclonal antibody specifically detects Prosaposin in WB, IHC, ELISA, ICC and FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for Prosaposin antibody (AA 17-216) (ABIN7193617)

Target: Prosaposin (PSAP)

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Prosaposin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 3B4A8

Product Details anti-Prosaposin Antibody

Binding Specificity: AA 17-216

Purpose: PSAP Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PSAP (AA: 17-216) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200-1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Prosaposin

Target: Prosaposin (PSAP)

Alternative Name: PSAP

Background:

This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Molecular Weight: 58.1 kDa

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity