HTR1F antibody (AA 70-150)

Catalog No. ABIN7217100

The Rabbit Polyclonal anti-HTR1F antibody (ABIN7217100) specifically detects HTR1F in WB, ELISA and IHC. The antibody is reactive with Human, Rat, Mouse and Monkey samples.

Quick Overview for HTR1F antibody (AA 70-150) (ABIN7217100)

Target: HTR1F (5-Hydroxytryptamine (serotonin) Receptor 1F (HTR1F))

Reactivity: Human, Rat, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HTR1F antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-HTR1F Antibody

Binding Specificity: AA 70-150

Purpose: Rabbit Anti-SR-1F Polyclonal Antibody

Specificity: SR-1F Polyclonal Antibody detects endogenous levels of SR-1F protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human SR-1F at AA range: 70-150

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for HTR1F

Target: HTR1F (5-Hydroxytryptamine (serotonin) Receptor 1F (HTR1F))

Alternative Name: SR-1F

Background: HTR1F, HTR1EL, 5-hydroxytryptamine receptor 1F, 5-HT-1F, 5-HT1F, Serotonin receptor 1FHTR1F (5-Hydroxytryptamine Receptor 1F) is a Protein Coding gene. Diseases associated with HTR1F include migraine with or without aura 1. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is DRD4. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Serotonin 5-HT1F receptors, previously known as 5-HT1Ebeta receptors, are located primarily in the hippocampus, cortex and dorsal raphe nucleus. The human 5-HT1F receptor is closely related to the 5-ht1E receptor and its gene has been localized to chromosome 3 (3q11).

Molecular Weight: 38kD

Gene ID: 3355

UniProt: P30939

Pathways: JAK-STAT Signaling