Adenosine A3 Receptor antibody (AA 230-310)

Catalog No. ABIN7219682

The Rabbit Polyclonal anti-Adenosine A3 Receptor antibody (ABIN7219682) specifically detects Adenosine A3 Receptor in WB, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Adenosine A3 Receptor antibody (AA 230-310) (ABIN7219682)

Target: Adenosine A3 Receptor (ADORA3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adenosine A3 Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-Adenosine A3 Receptor Antibody

Binding Specificity: AA 230-310

Purpose: Rabbit Anti-Adenosine A3-R Polyclonal Antibody

Specificity: Adenosine A3-R Polyclonal Antibody detects endogenous levels of Adenosine A3-R protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human Adenosine A3-R at AA range: 230-310

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IF 1:200-1:1000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Adenosine A3 Receptor

Target: Adenosine A3 Receptor (ADORA3)

Alternative Name: Adenosine A3-R

Background: ADORA3, Adenosine receptor A3ADORA3 encodes adenosine A3 receptor that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. ADORA3 shares its 5' terminal exon with some transcripts from overlapping GeneID: 57413, which encodes an immunoglobulin domain-containing protein.

Molecular Weight: 36kD

Gene ID: 140

UniProt: P33765

Pathways: Hormone Transport, cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process