Atrophin 1 antibody (AA 50-130)

Catalog No. ABIN7213736

This Rabbit Polyclonal antibody specifically detects Atrophin 1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Atrophin 1 antibody (AA 50-130) (ABIN7213736)

Target: Atrophin 1 (ATN1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Atrophin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Atrophin 1 Antibody

Binding Specificity: AA 50-130

Purpose: Rabbit Anti-Atrophin-1 Polyclonal Antibody

Specificity: Atrophin-1 Polyclonal Antibody detects endogenous levels of Atrophin-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human Atrophin-1 at AA range: 50-130

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Atrophin 1

Target: Atrophin 1 (ATN1)

Alternative Name: Atrophin-1

Background: ATN1, D12S755E, DRPLA, Atrophin-1, Dentatorubral-pallidoluysian atrophy proteinDentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.

Molecular Weight: 130kD

Gene ID: 1822

UniProt: P54259