BNIP3L/NIX antibody

Catalog No. ABIN7227504

The Rabbit Polyclonal anti-BNIP3L/NIX antibody is suitable to detect BNIP3L/NIX in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for BNIP3L/NIX antibody (ABIN7227504)

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BNIP3L/NIX antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-BNIP3L/NIX Antibody

Purpose: Rabbit Anti-BNI3L Polyclonal Antibody

Specificity: The antibody detects endogenous levels of BNI3L protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human BNI3L protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Alternative Name: BNI3L

Background: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, NIP3-like protein X, NIP3LBNIP3L encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. BNIP3L (BCL2 Interacting Protein 3 Like) is a Protein Coding gene. Diseases associated with BNIP3L include Glossopharyngeal Neuralgia and Glossopharyngeal Nerve Disease. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Apoptosis Modulation and Signaling.

Molecular Weight: 24kD

Gene ID: 665

UniProt: O60238

Pathways: Autophagy