BMP5 antibody (Internal Region)

Catalog No. ABIN7213822

This Rabbit Polyclonal antibody specifically detects BMP5 in WB, IHC, ELISA and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for BMP5 antibody (Internal Region) (ABIN7213822)

Target: BMP5 (Bone Morphogenetic Protein 5 (BMP5))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMP5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-BMP5 Antibody

Binding Specificity: Internal Region

Purpose: Rabbit Anti-BMP-5 Polyclonal Antibody

Specificity: BMP-5 Polyclonal Antibody detects endogenous levels of BMP-5 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human BMP-5

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for BMP5

Target: BMP5 (Bone Morphogenetic Protein 5 (BMP5))

Alternative Name: BMP-5

Background: BMP5, Bone morphogenetic protein 5, BMP-5BMP5 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. BMP5 encodes distinct protein isoforms that may be similarly proteolytically processed.

Molecular Weight: 52kD

Gene ID: 653

UniProt: P22003

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process