C1R antibody (Cleaved-Arg463)

Catalog No. ABIN7224738

The Rabbit Polyclonal anti-C1R antibody (ABIN7224738) specifically detects C1R in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for C1R antibody (Cleaved-Arg463) (ABIN7224738)

Target: C1R (Complement Component 1, R Subcomponent (C1R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1R antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-C1R Antibody

Binding Specificity: AA 390-470, Cleaved-Arg463

Purpose: Rabbit Anti-Cleaved-C1r HC (R463) Polyclonal Antibody

Specificity: Cleaved-C1r HC (R463) Polyclonal Antibody detects endogenous levels of fragment of activated C1r HC protein resulting from cleavage adjacent to R463.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human C1r HC at AA range: 390-470

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C1R

Target: C1R (Complement Component 1, R Subcomponent (C1R))

Alternative Name: C1r HC

Background: C1R, Complement C1r subcomponent, Complement component 1 subcomponent rThe first component of complement is a calcium-dependent complex of the 3 subcomponents C1q, C1r, and C1s. The serine protease subunits C1r and C1s form a Ca(2+)-dependent C1s-C1r-C1r-C1s tetramer. C1r acts by transforming the activation signal into an enzymic activity. C1r is a single-chain glycoprotein which can be cleaved into an A chain and a B chain upon activation. This antibody recognizes full-length C1r chain and the cleaved B chain.

Molecular Weight: 51kD

Gene ID: 715

UniProt: P00736

Pathways: Complement System